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ACS Appl Mater Interfaces 12(38):4269642703

Sideeffects are mild and transientdrowsiness, brief headache, vivid dreams, or occasional injectionsite irritationwithout tolerance or dependence Potential side effects include injection site irritation, headache, vivid dreams, and hormonerelated effects

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Furthermore, long-term exposure of cancer cells to acidic extracellular conditions induces metabolic reprogramming toward glutamine metabolism via HIF-2 activity 71

Medical oversight also gives space to discuss practical considerations, including expectations and cost